Formulation and Analytical Development for Low-Dose Oral Drug Products

GO Formulation and Analytical Development for Low-Dose Oral Drug Products


Author: Jack Zheng
Type: eBook
Language: English
Released: 2009
Publisher: Wiley
Page Count: 476
Format: pdf
ISBN-10: 0470056096
ISBN-13: 9780470056097
Tags:Formulation and Analytical Development for Low-Dose Oral Drug Products, tutorials, pdf, djvu, chm, epub, ebook, book, torrent, downloads, rapidshare, filesonic, hotfile, fileserve


Description:
The Practical, Easy-to-Use Guide to Lean Sigma Problem-Solving Lean Sigma delivers results—if you use the right tools and techniques. In Lean Sigma: A Practitioner’s Guide, Dr. Ian Wedgwood captures best-practice Lean Sigma experience from multiple projects and industries, helping any professional identify the solution that will work best—and implement it.   Wedgwood’s exclusive "project roadmaps" present the fastest, most effective route to solving a wide range of problems—and explain why those solutions make sense. His "discovery roadmaps" help you identify potential Lean Sigma projects, even in processes where there are no obvious targets.   The heart of Lean Sigma is Wedgwood's 48 individual "tools roadmaps": step-by-step instructions revealing exactly how and when to use all these Lean Sigma tools... • 5 Whys   • 5S   • Affinity   • ANOVA   • Boxplots   • Capability tools   • Cause & effect matrices   • Chi-Square   • Control charts   • Critical path analyses   • Customer tools   • Demand tools   • DOE tools   • Fishbone diagrams   • Handoff maps   • KPOVs   • Load charts   • MSA tools   • Multi-Cycle analyses   • Multi-Vari studies   • Murphy’s analyses   • Normality tests   • OEE   • Pareto charts   • Poka Yoke   • Process FMEA   • Process variables (I/O) maps   • Project charter   • Pull systems & Kanban   • Rapid changeover   • Regression   • SIPOC   • Spaghetti maps   • SPC   • Swimlane maps   • Time tools   Whether you’re a Green Belt, Black Belt, Master, Project Champion, Sponsor, Deployment Leader, or consultant, this book will help you use Lean Sigma to solve far more problems, far more rapidly, and far more effectively.   Dr. Ian Wedgwood, Executive Director of Sigma Breakthrough Technologies, has more than ten years of experience using, deploying, training, and consulting on Six Sigma and Lean Sigma. He has led and facilitated deployments in industries ranging from electronics and medical devices to chemicals and health care, and has trained and mentored numerous executives, champions, and belts. He holds a Ph.D. and First-Class Honors degree in Applied Mathematics from Scotland’s St. Andrew’s University.   Chapter 1    Introduction 1 PART I        PROJECT ROADMAPS TO SOLVE BUSINESS PROBLEMS Chapter 2    Define—Tools Roadmap Applied to the Beginning of All Projects   13 Chapter 3    Global Process Problems  23           A: On-Time Delivery Issues        23           B: Capacity of Process Is Too Low      27           C: RTY, Defects, Accuracy, Quality, Scrap, and Rework Issues    29           D: % Uptime Is Too Low 33           E: Pace of Process Too Slow     36           F: Process Has Enough Capacity, But Fails Intermittently   38           G: Process Has Enough Capacity, But Process Lead Time Is Too Long  41           H: Individual Steps Meet Takt, Global Process Does Not    44           I: Demand from the Customer Is Too Variable        47           J: Too Many Entity Types (Products)   51           K: High Schedule Variation         54           L: Measurement System Broken         60           M: Performance Characteristic Not Good Enough    63           N: Planned Maintenance Takes Too Long       64           O: Setup/Changeover Takes Too Long          65           P: Too Much Unplanned Maintenance   68           Q: Process Can’t Make Product at All   72           R: Resource Usage Is Too High (Headcount Reduction)     75           S: Inventory Is Too High  78           T: Waste/Process Loss Too High         82           U: High Forecast Variation         85           V: Not Enough Sales        89           W: Backlog of Orders Is Too High        91           X: Payments Made to Suppliers Not Optimized        93           Y: Accounts Receivable Are Too High   95 Chapter 4    Individual Step Process Problems         99 Chapter 5    Control—Tools Used at the End of All Projects         107 PART II      ROADMAPS TO FIND PROJECTS WHERE NO OBVIOUS CAND... From the Back Cover The Practical, Easy-to-Use Guide to Lean Sigma Problem-Solving Lean Sigma delivers results—if you use the right tools and techniques. In Lean Sigma: A Practitioner’s Guide, Dr. Ian Wedgwood captures best-practice Lean Sigma experience from multiple projects and industries, helping any professional identify the solution that will work best—and implement it.   Wedgwood’s exclusive "project roadmaps" present the fastest, most effective route to solving a wide range of problems—and explain why those solutions make sense. His "discovery roadmaps" help you identify potential Lean Sigma projects, even in processes where there are no obvious targets.   The heart of Lean Sigma is Wedgwood's 48 individual "tools roadmaps": step-by-step instructions revealing exactly how and when to use all these Lean Sigma tools... • 5 Whys   • 5S   • Affinity   • ANOVA   • Boxplots   • Capability tools   • Cause & effect matrices   • Chi-Square   • Control charts   • Critical path analyses   • Customer tools   • Demand tools   • DOE tools   • Fishbone diagrams   • Handoff maps   • KPOVs   • Load charts   • MSA tools   • Multi-Cycle analyses   • Multi-Vari studies   • Murphy’s analyses   • Normality tests   • OEE   • Pareto charts   • Poka Yoke   • Process FMEA   • Process variables (I/O) maps   • Project charter   • Pull systems & Kanban   • Rapid changeover   • Regression   • SIPOC   • Spaghetti maps   • SPC   • Swimlane maps   • Time tools   Whether you’re a Green Belt, Black Belt, Master, Project Champion, Sponsor, Deployment Leader, or consultant, this book will help you use Lean Sigma to solve far more problems, far more rapidly, and far more effectively.   Dr. Ian Wedgwood, Executive Director of Sigma Breakthrough Technologies, has more than ten years of experience using, deploying, training, and consulting on Six Sigma and Lean Sigma. He has led and facilitated deployments in industries ranging from electronics and medical devices to chemicals and health care, and has trained and mentored numerous executives, champions, and belts. He holds a Ph.D. and First-Class Honors degree in Applied Mathematics from Scotland’s St. Andrew’s University.   Chapter 1    Introduction 1 PART I        PROJECT ROADMAPS TO SOLVE BUSINESS PROBLEMS Chapter 2    Define—Tools Roadmap Applied to the Beginning of All Projects   13 Chapter 3    Global Process Problems  23           A: On-Time Delivery Issues        23           B: Capacity of Process Is Too Low      27           C: RTY, Defects, Accuracy, Quality, Scrap, and Rework Issues    29           D: % Uptime Is Too Low 33           E: Pace of Process Too Slow     36           F: Process Has Enough Capacity, But Fails Intermittently   38           G: Process Has Enough Capacity, But Process Lead Time Is Too Long  41           H: Individual Steps Meet Takt, Global Process Does Not    44           I: Demand from the Customer Is Too Variable        47           J: Too Many Entity Types (Products)   51           K: High Schedule Variation         54           L: Measurement System Broken         60           M: Performance Characteristic Not Good Enough    63           N: Planned Maintenance Takes Too Long       64           O: Setup/Changeover Takes Too Long          65           P: Too Much Unplanned Maintenance   68           Q: Process Can’t Make Product at All   72           R: Resource Usage Is Too High (Headcount Reduction)     75           S: Inventory Is Too High  78           T: Waste/Process Loss Too High         82           U: High Forecast Variation         85           V: Not Enough Sales        89           W: Backlog of Orders Is Too High        91           X: Payments Made to Suppliers Not Optimized        93           Y: Accounts Receivable Are Too High   95 Chapter 4    Individual Step Process Problems         99 Chapter 5    Control—Tools Used at the End of All Projects         107 PART II      ROADMAPS TO FIND PROJECTS WHERE NO OBVIOUS CAND...